Brainstorming Entrepreneurship in Brain Health

The burgeoning field of brain health innovation demands a convergence of clinical insight and entrepreneurial strategy. Despite the immense global burden of neurological disorders and associated economic costs, there are precious few examples of evidence-based and scalable innovations addressing these challenges. To bridge this gap, the multidisciplinary forum Brainstorme! Entrepreneurship in Brain Health convened on October 5, 2024, in Los Angeles, bringing together physicians, scientists, investors, and industry leaders to share actionable insights on advancing diagnostics, digital health solutions, drug development, and devices in neurology. This article encapsulates the event's key themes, emphasizing unique stakeholder strategies to accelerate innovation while aligning with the health care value chain and the triple aim of improved patient experience, population outcomes, and cost efficiency. We highlight a case study of Brainstorme, a cloud-based brain imaging platform, to illustrate how entrepreneurial initiatives can address unmet needs, leveraging new federal interoperability rules and novel business models, to empower patients and reduce system inefficiencies. Finally, we integrate perspectives from recent literature on early-career physician entrepreneurship, digital health, and health economics to underscore how innovation can be cultivated within an ecosystem that values collaboration, evidence generation, and sustainable value creation.