DNAJB13 polymorphisms and association with idiopathic asthenozoospermia in Sichuan, China
The c.T272G (p.V91G) in DNAJB13 is significantly associated with IAZS in the studied cohort and represents a potential high-risk genetic factor. Predicted detrimental effects on protein structure and function suggest a novel genetic mechanism underlying impaired sperm motility. Functional validation and replication studies in diverse populations are necessary to confirm its pathogenic role.
Authors
- Xianping Ding (ORCID: https://orcid.org/0000-0003-1555-5028)
- Chunlan Cheng
- Jiaoyu He (ORCID: https://orcid.org/0000-0003-4585-1354)
- Chengyue Wang (ORCID: https://orcid.org/0000-0002-8886-2523)
- Ning Li (ORCID: https://orcid.org/0000-0003-4178-5054)
- Tianjun Li (ORCID: https://orcid.org/0000-0001-5280-595X)
- Xianqiong Zhao
- Yongling Ding (ORCID: https://orcid.org/0009-0002-2342-276X)
- Zhuo Zhang (ORCID: https://orcid.org/0000-0003-3258-7849)
Institutions
- Jiangxi University of Water Resources and Electric Power (CN)
- Chongqing University (CN)
- Sichuan University (CN)
- Sichuan International Studies University (CN)
- Huzhou Vocational and Technical College (CN)
- West China Second University Hospital of Sichuan University (CN)
- Chengdu Women's and Children's Central Hospital (CN)
- Maternal and Child Health Hospital of Sichuan Province (CN)
- Chengdu Second People's Hospital (CN)
Publication Details
- Journal
- Basic and Clinical Andrology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s12610-025-00295-w
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00