Asymmetric Olefin Cyclopropanation Catalyzed by Pincer Ruthenium Complexes
We report the development of a class of chiral pincer ruthenium (PCN<sub>Ox</sub>)Ru complexes bearing oxazoline-based PCN<sub>Ox</sub> ligands for the asymmetric cyclopropanation of olefins with α-diazo carbonyl compounds. These catalysts exhibit high reactivity and stereoselectivity across a broad range of substrates, including monosubstituted, 1,1-disubstituted, and challenging trisubstituted olefins. The present catalyst showed superior performance in the asymmetric intermolecular cyclopropanation of trisubstituted olefins compared to the known (Pheox)Ru catalyst.
Authors
- Shunlong He
- Bo Chai (ORCID: https://orcid.org/0000-0002-0684-9254)
- Lan Gan (ORCID: https://orcid.org/0000-0002-8215-2897)
- Zheng Huang (ORCID: https://orcid.org/0000-0001-7524-098X)
- Qi‐Kai Kang (ORCID: https://orcid.org/0009-0008-0473-9335)
- Guixia Liu (ORCID: https://orcid.org/0000-0001-7565-2183)
Institutions
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1021/acs.orglett.5c04950
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00