Electrochemical cross-electrophile coupling of unactivated tertiary alkyl bromides with benzyl chloride to access quaternary stereocenters
Constructing quaternary carbon centers represents a significant yet challenging task in synthetic and medicinal chemistry. Herein, we report an efficient electrochemical nickel-catalyzed reductive cross-electrophile coupling for the modular synthesis of diverse quaternary carbon centers from readily available tertiary alkyl bromides and benzyl chlorides. This electrochemical protocol eliminates the dependence on stoichiometric metallic reductants, making this method more sustainable and attractive.
Authors
- Weichao Xue (ORCID: https://orcid.org/0000-0002-8376-9485)
- Ying Tan (ORCID: https://orcid.org/0000-0001-8243-4731)
- Xueli Zheng (ORCID: https://orcid.org/0000-0001-8394-0310)
- Jiaqi Xu (ORCID: https://orcid.org/0000-0002-2774-5016)
- Shaokun Tao
- Haiyan Fu (ORCID: https://orcid.org/0000-0002-7185-2062)
- Li Chen (ORCID: https://orcid.org/0000-0001-8820-1496)
- Hua Chen (ORCID: https://orcid.org/0000-0003-4248-8019)
- Ruixiang Li (ORCID: https://orcid.org/0000-0003-0756-3722)
- Yun Yang (ORCID: https://orcid.org/0000-0003-3781-000X)
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1039/d5ob01873k
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00