FOXA2 as a SETD1A-Regulated Driver of Tamoxifen Resistance in Breast Cancer
Our findings identified FOXA2 as a key mediator of tamoxifen resistance regulated by SETD1A and suggested that targeting the SETD1A-FOXA2 axis may offer a novel strategy for overcoming endocrine resistance in breast cancer.
Authors
- Jae Rim Lee
- Kwang Won Jeong (ORCID: https://orcid.org/0000-0003-2258-8354)
- Minsoo Kim (ORCID: https://orcid.org/0000-0001-6304-6901)
- Xiaohan Zhang (ORCID: https://orcid.org/0000-0001-7964-3938)
Institutions
- Gachon University (KR)
- Guizhou University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-12-18
- DOI
- https://doi.org/10.32604/or.2025.072592
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00