Antibiotic Use Thresholds for Carbapenem-Resistant Gram-Negative Bacteria: A Nonlinear Time-Series Study

AUD is associated with the detection rates of CRGN. To reduce the detection rates of CRGN, we determined thresholds for carbapenems, aminoglycosides, fluoroquinolones, and glycopeptides at 5.82, 0.06, 7.09, and 0.77 Defined Daily Doses (DDDs)/(100 patient-days), respectively.

Authors

Jinlong Yu (ORCID: https://orcid.org/0000-0002-5234-9285)
Fang Qian (ORCID: https://orcid.org/0000-0002-8040-3509)
Qingxin Luo
Chen Chen (ORCID: https://orcid.org/0000-0002-4885-393X)
Shuxian Wang (ORCID: https://orcid.org/0009-0004-2746-9666)
Chao Sun (ORCID: https://orcid.org/0000-0002-8055-1640)

Institutions

Shandong University (CN)
Second Hospital of Shandong University (CN)
Yantaishan Hospital (CN)
Qilu Hospital of Shandong University (CN)

Publication Details

Journal: Infection and Drug Resistance
Published: 2025-12-01
DOI: https://doi.org/10.2147/idr.s556821
Primary Topic: Antibiotics Pharmacokinetics and Efficacy
Type: article
Field-Weighted Citation Impact: 0.00

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article

Antibiotic Use Thresholds for Carbapenem-Resistant Gram-Negative Bacteria: A Nonlinear Time-Series Study

Jinlong Yu, Fang Qian, Qingxin Luo, Chen Chen et al.

Dec 1, 2025

Infection and Drug Resistance

Antibiotics Pharmacokinetics and Efficacy

article

Antibiotic Use Thresholds for Carbapenem-Resistant Gram-Negative Bacteria: A Nonlinear Time-Series Study

Jinlong Yu, Fang Qian, Qingxin Luo, Chen Chen, Shuxian Wang, Chao Sun

December 1, 2025article en

Abstract

AUD is associated with the detection rates of CRGN. To reduce the detection rates of CRGN, we determined thresholds for carbapenems, aminoglycosides, fluoroquinolones, and glycopeptides at 5.82, 0.06, 7.09, and 0.77 Defined Daily Doses (DDDs)/(100 patient-days), respectively.

Infection and Drug ResistanceVol. Volume 18

Shandong University (CN), Second Hospital of Shandong University (CN), Yantaishan Hospital (CN), Qilu Hospital of Shandong University (CN)

Openalex Percentile: Top 56%

Antibiotics Pharmacokinetics and Efficacy

DOI Open Access PDF OpenAlex

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Antibiotic Use Thresholds for Carbapenem-Resistant Gram-Negative Bacteria: A Nonlinear Time-Series Study — Jinlong Yu, Fang Qian, et al. · Infection and Drug Resistance (2025) | TGRS Research Map | TGRS