Autonomic dysfunctions in psychotic disorders, interaction with antipsychotic intervention and treatment resistance: a comprehensive systematic review and meta-analysis

These results suggest that ANS dysregulations may be a core feature of psychosis, only partially dependent on pharmacological treatment, suggesting a potential primary dysregulation within the Central Autonomic Network. Disruptions in neurotransmitter systems, particularly acetylcholine, may contribute. Autonomic profiling could refine psychiatric diagnosis, helping with tailored interventions. Longitudinal studies are needed to explore their potential in predicting treatment response.