Butyrate improves dextran sulfate sodium-induced imbalance of intestinal stem cell homeostasis in broilers

The findings imply that butyrate might promote ISC self-renewal and differentiation, improving the structure and function of the intestinal lining by triggering the Wnt/β-catenin and Notch signaling pathways. The study provides clinical value by highlighting the key role of immunometabolism in intestinal diseases and potential therapeutic targets, and it has broad application prospects in livestock and poultry farming for improving growth performance by enhancing gut health.