Circulating tumour DNA as a prognostic tool for surgically treated pancreatic ductal adenocarcinoma
Our data indicate that detectable ctDNA in plasma taken before and 7-9 months after surgery holds independent prognostic value in PDAC. Combination of ctDNA with CA-19-9 may be a particularly strong prognosticator, which should be confirmed in future studies.
Authors
- Karin de Stricker
- Tenna Vesterman Henriksen (ORCID: https://orcid.org/0000-0002-8541-1735)
- Frank Viborg Mortensen (ORCID: https://orcid.org/0000-0001-7580-8037)
- Carlos Fernández Moro (ORCID: https://orcid.org/0000-0001-6863-5959)
- Jörg Kleeff (ORCID: https://orcid.org/0000-0003-3432-6669)
- Ernesto Sparrelid (ORCID: https://orcid.org/0000-0003-0259-8328)
- Claus L. Andersen (ORCID: https://orcid.org/0000-0002-7406-2103)
- Michael Bau Mortensen (ORCID: https://orcid.org/0000-0002-7270-5005)
- Lea Lecanda Mariager Jakobsen
- Per Pfeiffer (ORCID: https://orcid.org/0000-0002-2925-0586)
- Claus Wilki Fristrup (ORCID: https://orcid.org/0000-0003-2721-0967)
- Stephen Jacques Hamilton-Dutoit (ORCID: https://orcid.org/0000-0003-2158-3885)
- Anders Riegels Knudsen (ORCID: https://orcid.org/0000-0002-5630-8317)
- Trine Aaquist (ORCID: https://orcid.org/0000-0002-5400-6665)
- Sönke Detlefsen (ORCID: https://orcid.org/0000-0002-9466-2333)
Institutions
- Karolinska University Hospital (SE)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Human Pathology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1016/j.humpath.2025.106024
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dagmar Marshalls Fond
- Axel Muusfeldts Fond
- Aase og Ejnar Danielsens Fond
- A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal
- Syddansk Universitet
- Frimodt-Heineke Fonden
- Fabrikant Einar Willumsens Mindelegat
- Ingeniør K. A. Rohde og hustrus Legat