Cost-effectiveness analysis of surgical and non-surgical weight loss interventions in end-stage knee osteoarthritis and obesity: a Markov State model
Bariatric surgery is effective and cost-effective in delaying or preventing TKA in patients with severe obesity and reducing the need for primary and secondary surgical revision. Despite current limitations on the long-term effects of available antiobesity medications, semaglutide appears to also be cost-effective, while non-surgical weight loss is the least effective strategy. Clinicians and policy makers should consider the cost-effectiveness of losing weight prior to total knee replacement in patients with obesity.
Authors
- Esmeralda Capristo (ORCID: https://orcid.org/0000-0002-5753-3495)
- Sabina Maltese
- Stefan R. Bornstein (ORCID: https://orcid.org/0000-0002-5211-2536)
- Geltrude Mingrone (ORCID: https://orcid.org/0000-0003-2021-528X)
- Laura D’Orsi (ORCID: https://orcid.org/0000-0003-4899-9573)
- Andrea De Gaetano (ORCID: https://orcid.org/0000-0001-7712-056X)
- Marcello Pompa (ORCID: https://orcid.org/0000-0001-9757-6310)
- Simona Panunzi (ORCID: https://orcid.org/0000-0003-0956-8578)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Obuda University (HU)
- King's College London (GB)
- Agostino Gemelli University Polyclinic (IT)
- King's College School (GB)
- Institute for Biomedical Research and Innovation (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti (IT)
- Klinik und Poliklinik für Psychotherapie und Psychosomatik (DE)
Publication Details
- Journal
- BMC Public Health
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s12889-025-25427-9
- Primary Topic
- Total Knee Arthroplasty Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00