Efficacy and safety of GW117 tablets in major depressive disorder: a randomised, double-blind, placebo-controlled, phase 2 dose-finding study

Authors

Wei Gu (ORCID: https://orcid.org/0009-0003-0892-5585)
Zhiqiang Wang (ORCID: https://orcid.org/0009-0003-5236-3559)
Zhaoji Dong (ORCID: https://orcid.org/0009-0009-5613-4407)
Xiaolan Di (ORCID: https://orcid.org/0009-0000-4665-4227)
R.J. Wang (ORCID: https://orcid.org/0009-0003-4467-6491)
Jie Li (ORCID: https://orcid.org/0000-0001-5408-8413)
Xianhui Hao (ORCID: https://orcid.org/0009-0000-6895-7245)
Jingli Wang (ORCID: https://orcid.org/0009-0000-0695-5818)
Yifeng Shen (ORCID: https://orcid.org/0000-0002-3298-6682)
Xiaoning Shi (ORCID: https://orcid.org/0009-0005-0254-9253)
Yang Hai-bo (ORCID: https://orcid.org/0009-0009-8633-3423)
Guangyong Zhang (ORCID: https://orcid.org/0009-0006-7801-9029)
YU Xue-qin (ORCID: https://orcid.org/0009-0005-3452-6574)
Hongyan Zhang (ORCID: https://orcid.org/0000-0001-5137-4254)
Jing-Jing Liu (ORCID: https://orcid.org/0000-0001-7484-1580)
Tao Zhiping (ORCID: https://orcid.org/0009-0005-8371-9700)
Xueyi Wang (ORCID: https://orcid.org/0000-0002-0798-2049)
Yingli Zhang (ORCID: https://orcid.org/0009-0003-6608-5596)
Zhiwei Jiang (ORCID: https://orcid.org/0009-0009-8237-5570)

Institutions

Hebei Medical University (CN)
Harbin Medical University (CN)
Capital Medical University (CN)
Peking University (CN)
Shanghai Mental Health Center (CN)
Daqing City People's Hospital (CN)
Zhumadian Central Hospital (CN)
Mianyang Third People's Hospital (CN)
Chongqing City Mental Health Center (CN)
Tianjin Anding Hospital (CN)
National Institutes of Pharmaceutical Research and Development (China) (CN)
Beijing Anding Hospital (CN)
Shenzhen KangNing Hospital (CN)
Jiangxi Mental Health Center (CN)
Jinzhou Kangning Hospital (CN)
Beijing HuiLongGuan Hospital (CN)
First Affiliated Hospital of Hebei Medical University (CN)
Statistical Research (United States) (US)
National Supercomputing Center in Wuxi (CN)
Brain Hospital of Jilin (CN)
Peking University Sixth Hospital (CN)

Publication Details

Journal: General Psychiatry
Published: 2025-12-01
DOI: https://doi.org/10.1136/gpsych-2025-102337
Primary Topic: Treatment of Major Depression
Type: article
Field-Weighted Citation Impact: 0.00

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article

Efficacy and safety of GW117 tablets in major depressive disorder: a randomised, double-blind, placebo-controlled, phase 2 dose-finding study

Wei Gu, Zhiqiang Wang, Zhaoji Dong, Xiaolan Di et al.

Dec 1, 2025

General Psychiatry

Treatment of Major Depression

article

Efficacy and safety of GW117 tablets in major depressive disorder: a randomised, double-blind, placebo-controlled, phase 2 dose-finding study

Wei Gu, Zhiqiang Wang, Zhaoji Dong, Xiaolan Di, R.J. Wang, Jie Li, Xianhui Hao, Jingli Wang, Yifeng Shen, Xiaoning Shi, Yang Hai-bo, Guangyong Zhang, YU Xue-qin, Hongyan Zhang, Jing-Jing Liu, Tao Zhiping, Xueyi Wang, Yingli Zhang, Zhiwei Jiang

December 1, 2025article en

Abstract

No abstract available for this paper.

General PsychiatryVol. 38(6)

Hebei Medical University (CN), Harbin Medical University (CN), Capital Medical University (CN), Peking University (CN), Shanghai Mental Health Center (CN), Daqing City People's Hospital (CN), Zhumadian Central Hospital (CN), Mianyang Third People's Hospital (CN), Chongqing City Mental Health Center (CN), Tianjin Anding Hospital (CN), National Institutes of Pharmaceutical Research and Development (China) (CN), Beijing Anding Hospital (CN), Shenzhen KangNing Hospital (CN), Jiangxi Mental Health Center (CN), Jinzhou Kangning Hospital (CN), Beijing HuiLongGuan Hospital (CN), First Affiliated Hospital of Hebei Medical University (CN), Statistical Research (United States) (US), National Supercomputing Center in Wuxi (CN), Brain Hospital of Jilin (CN), Peking University Sixth Hospital (CN)

Openalex Percentile: Top 56%

Treatment of Major Depression

DOI Open Access PDF OpenAlex

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