A Phase 1b/2, Randomised, Placebo-controlled Study to Evaluate Safety, Tolerability, Efficacy, and Immunogenicity of VTP-200, a Chimpanzee Adenovirus and Modified Vaccinia Ankara-vectored Multigenotype High-risk Human Papillomavirus Vaccine in Women
A heterologous, multi-antigenic HPV two-component immunotherapy regimen was well-tolerated and immunogenic but did not result in a statistically significant clearance of either hrHPV or the associated cervical lesions in women with persistent high-risk HPV infections.
Authors
- Katie Anderson (ORCID: https://orcid.org/0000-0001-7910-8003)
- Thomas G. Evans (ORCID: https://orcid.org/0000-0001-9917-3363)
- Vicky Wheeler (ORCID: https://orcid.org/0009-0005-4886-7257)
- Sarah Sebastian (ORCID: https://orcid.org/0000-0001-7918-4321)
- Gemma Hancock (ORCID: https://orcid.org/0000-0001-9072-2493)
- Kobe Dewilde (ORCID: https://orcid.org/0000-0002-7454-7282)
- Paula Briggs (ORCID: https://orcid.org/0000-0003-0468-9151)
- Kate Cuschieri (ORCID: https://orcid.org/0000-0002-2604-3928)
- Lucy Dorrell
- Charlotte Davis (ORCID: https://orcid.org/0000-0002-2701-2226)
- Dereck Tait (ORCID: https://orcid.org/0000-0002-8683-238X)
- P. De Sutter (ORCID: https://orcid.org/0000-0002-3064-3344)
- Karin Hellner (ORCID: https://orcid.org/0000-0002-4330-4720)
- Philipp W. Simon (ORCID: https://orcid.org/0000-0001-6978-6062)
- Antonella Vardeu
- Kadri-Liina Vahula
- Bethan Jones (ORCID: https://orcid.org/0000-0002-1931-4398)
- Matthew Downs (ORCID: https://orcid.org/0000-0002-3623-8059)
- Michelle Russell
- Jakub Kopycinski
- Claire Newton (ORCID: https://orcid.org/0000-0003-3621-0387)
- Raisha Kennerley
- Ülle Kiisla
Institutions
- University of Liverpool (GB)
- Universitair Ziekenhuis Leuven (BE)
- Royal Victoria Infirmary (GB)
- Women's and Children's Hospital (AU)
- Directorate-General for Health and Food Safety (BE)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Erasmus Hospital (BE)
- Edinburgh Royal Infirmary (GB)
- University of Oxford (GB)
- North Estonia Medical Centre (EE)
- Clinique Saint Jean (BE)
- St Michael's Hospital (GB)
- Atara Biotherapeutics (United States) (US)
- Liverpool Womens NHS Foundation Trust (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1093/cid/ciaf658
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00