Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms
This exploratory study suggests that CHI3L1 is a fibroblast-enriched molecule closely associated with immune dysregulation and RA activity, showing promise as a diagnostic and monitoring biomarker and a potential therapeutic target, though further validation through functional experiments and prospective studies is warranted.
Authors
- Ya Ding (ORCID: https://orcid.org/0000-0001-6214-5641)
- Yanqun Huang (ORCID: https://orcid.org/0000-0002-4427-2767)
- Chao Wang (ORCID: https://orcid.org/0009-0001-3192-253X)
- Dan Wang (ORCID: https://orcid.org/0000-0001-8388-9842)
- Ming Lei (ORCID: https://orcid.org/0000-0001-7971-6447)
- D. Yi
- Langui Tang
- Yan Gao (ORCID: https://orcid.org/0009-0007-2701-2115)
- Kaiyun Guo
Institutions
- Central South University (CN)
- The First People's Hospital of Changde (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1729989
- Citations
- 1
- Primary Topic
- Studies on Chitinases and Chitosanases
- Type
- article
- Field-Weighted Citation Impact
- 0.81