Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study
We identified that immune-inflammatory profiles and radiological-clinical factors are significant predictors for treatment response and OS in NSCLC patients with BM undergoing SRS. The developed decision tree and nomogram models, which incorporate immune-inflammatory profiles, provide user-friendly tools to assist clinicians in optimizing personalized management for this patient population.
Authors
- Peng Du (ORCID: https://orcid.org/0000-0002-6970-1329)
- Shenao Zhang
- Aihong Cao
- Hongxia Zhao (ORCID: https://orcid.org/0000-0003-3934-8082)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0002-6968-0302)
- Yinjiao Wang
Institutions
- Xuzhou Medical College (CN)
- Second Affiliated Hospital of Xuzhou Medical College (CN)
- Xuzhou No.1 People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1739812
- Citations
- 2
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Jiangsu Commission of Health
- Xuzhou Medical University
- Xuzhou Science and Technology Bureau