CD4+ T cells stratification unveils a dynamic pathogen landscape in severe pneumonia: a targeted next-generation sequencing-based cohort study
The CD4<sup>+</sup> T cells count quantitatively defines the pathogen ecology in pulmonary infections. A CD4<sup>+</sup> T cells count < 100 cells/μL represents a critical threshold for opportunistic infections and complex co-infections. These findings support the integration of CD4<sup>+</sup> T cells counting into the initial assessment framework for severe pneumonia to guide precise empirical therapy and diagnostic strategies.
Authors
- Na Du (ORCID: https://orcid.org/0009-0006-0805-1680)
- Luyao Sun (ORCID: https://orcid.org/0000-0001-7767-8408)
- Yue Yu (ORCID: https://orcid.org/0000-0002-9865-2212)
- Shuaishuai Wang (ORCID: https://orcid.org/0000-0002-4761-8292)
- Minglei Zhang (ORCID: https://orcid.org/0000-0001-6227-4240)
- Che Lihe
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fcimb.2025.1742311
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00