Thyroid Hormone Dysregulation and Lipid Metabolism Alterations in Bipolar Disorder: Associations With Manic Episodes, Aggressive Behaviour and Cognitive Impairment

Changes in lipid metabolism indicators and thyroid hormone levels in patients with bipolar disorder are closely related to manic episodes, aggressive behaviours and cognitive dysfunction, but no correlation was found with disease severity. This evidence supports precision management of bipolar disorder by utilizing specific lipid and thyroid hormone profiles to guide cardiovascular screening, aggression risk assessment, and early detection of cognitive decline.