Neuroimmune Crossroads: Pathophysiological Links Between Bipolar Disorder and Inflammatory Bowel Disease
The intersection of BD and IBD underscores a bidirectional gut-brain neuroimmune axis, with systemic inflammation as a central mediator. Recognizing and managing this comorbidity requires integrated multidisciplinary care. Future research should focus on longitudinal studies and targeted anti-inflammatory interventions to improve outcomes in this high-risk population.
Authors
- Eleonora Gaetani (ORCID: https://orcid.org/0000-0002-7808-1491)
- Francesco Maria Lisci (ORCID: https://orcid.org/0000-0002-3314-142X)
- Roberto Pola (ORCID: https://orcid.org/0000-0001-5224-2931)
- Antonio Gasbarrini (ORCID: https://orcid.org/0000-0002-6230-1779)
- Gabriele Sani (ORCID: https://orcid.org/0000-0002-9767-8752)
- Marianna Mazza (ORCID: https://orcid.org/0000-0002-3007-8162)
- Caterina Brisi (ORCID: https://orcid.org/0000-0002-0491-5051)
- Emanuele Caroppo (ORCID: https://orcid.org/0000-0001-9602-8208)
- Francesca Bardi (ORCID: https://orcid.org/0009-0009-2187-320X)
- Emanuela De Chiara (ORCID: https://orcid.org/0009-0009-2772-1805)
- Giuseppe Marano (ORCID: https://orcid.org/0000-0001-7058-4927)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Regional Health (US)
- Azienda Sanitaria Locale Roma 3 (IT)
Publication Details
- Journal
- Actas Españolas de Psiquiatría
- Published
- 2025-12-17
- DOI
- https://doi.org/10.62641/aep.v53i6.2001
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00