Unmasking inflammation in juvenile dermatomyositis: myokine profiles of patients and bioengineered human muscle
JDM patients have a pro-inflammatory myokine profile in blood and muscle that can be recapitulated in IFN-stimulated myobundles. CXCL9 and CXCL10 are promising biomarkers, as are IL-6, IL-15, and IL-18, for JDM muscle activity. Our findings validate the myobundle model as a platform for studying JDM and support muscle as a key source of pathologic inflammation.
Authors
- George A. Truskey (ORCID: https://orcid.org/0000-0002-6885-4489)
- Jeffrey Dvergsten (ORCID: https://orcid.org/0000-0002-3492-9665)
- Jessica L. Turnier (ORCID: https://orcid.org/0000-0002-1127-7879)
- Sema Kandil (ORCID: https://orcid.org/0000-0002-5331-5378)
- Lauren T. Covert (ORCID: https://orcid.org/0000-0003-1362-5635)
- Jessica Neely
- Kaveh Ardalan (ORCID: https://orcid.org/0000-0002-5552-4501)
Institutions
- Duke University (US)
- University of California, San Francisco (US)
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1694717
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00