Rethinking Treatment-Resistant Depression: A Systematic Review of Novel Therapeutic Strategies and Precision Medicine Approaches
A multidisciplinary and precision-based approach is essential for optimizing TRD management. Future research should focus on biomarker-driven treatment selection, artificial intelligence-assisted decision making, and large-scale trials to refine personalized therapeutic strategies.
Authors
- Safiye Zeynep Tatlı (ORCID: https://orcid.org/0000-0003-2103-4763)
- Murat İlhan Atagün (ORCID: https://orcid.org/0000-0002-8514-0576)
Institutions
- Çanakkale Onsekiz Mart Üniversitesi (TR)
- Memorial Ankara Hospital (TR)
Publication Details
- Journal
- Actas Españolas de Psiquiatría
- Published
- 2025-12-17
- DOI
- https://doi.org/10.62641/aep.v53i6.1946
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00