Sulfate reducing bacteria induce α-synuclein in intestinal and neuronal cells and tissues and inhibit tyrosine hydroxylase in neuronal cells
Thus, our findings provide a gut-to-brain link tied to the ability of SRB in the gut-to increase expression, aggregation and spread of α-syn and decrease of TH in PD.
Authors
- Sephira G. Ryman (ORCID: https://orcid.org/0000-0002-1758-3391)
- Cody A. Braun
- Henry C. Lin (ORCID: https://orcid.org/0000-0002-1263-5404)
- Sudha Singh (ORCID: https://orcid.org/0000-0001-6925-8286)
- Amanda Carroll‐Portillo (ORCID: https://orcid.org/0000-0001-9089-2601)
- Arianne J. Capacio
Institutions
- Mind Research Network (US)
- University of New Mexico (US)
- Biomedical Research Institute of New Mexico (US)
- New Mexico VA Health Care System (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fnins.2025.1672793
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00