The role of immune cells-mediated memory in weight cycling, glucose disorders and insulin resistance

Weight cycling (WC), defined as the repeated process of weight gain and loss, is one of the biggest challenges in the management of weight. It is estimated that the majority of individuals (60%) will regain their lost weight within a few years. There is a positive correlation between WC and the increased risk of metabolic diseases. Although multiple factors probably contribute to this variation, immune cells-mediated immune memory plays a key role. In this review, we showed that immune memory is one of the core mechanisms of WC, glucose and insulin disorders. Immune cells, such as macrophages, CD4+ T cells, CD8+ T cells, Treg cells and CD7+ monocytes, were included. We also exhibited potential therapies to prevent WC targeting immune memory.