Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations
This study establishes MALDI-MSI as a powerful platform for pharmacometabolomic evaluation, while elucidating matrine's therapeutic potential through coordinated regulation of lipid metabolic remodeling, amino acid/nucleotide biosynthesis pathways and oxidative stress responses. Our findings provide mechanistic insights into matrine's anticancer action and validate metabolomic approaches for natural product evaluation.
Authors
- Xiaojing An (ORCID: https://orcid.org/0000-0002-4340-2785)
- Hua Guo (ORCID: https://orcid.org/0000-0001-9901-053X)
- Xiao Liang (ORCID: https://orcid.org/0000-0002-0103-0354)
- Juexin Wang (ORCID: https://orcid.org/0000-0002-2260-4310)
- Qi Li (ORCID: https://orcid.org/0000-0001-7380-8703)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0001-9885-356X)
- Lulu Chen (ORCID: https://orcid.org/0000-0001-9621-9231)
- Wenjuan Liu (ORCID: https://orcid.org/0009-0003-6048-5273)
- Qin Liang (ORCID: https://orcid.org/0000-0002-2018-8333)
- Rong Wu (ORCID: https://orcid.org/0000-0002-0485-2249)
- Jia Xu (ORCID: https://orcid.org/0000-0002-3376-853X)
- Fengmei Wang (ORCID: https://orcid.org/0000-0001-9287-4183)
Institutions
- Minzu University of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Forestry University (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fphar.2025.1627864
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences
- National Ethnic Affairs Commission of the People's Republic of China