Disruption of Swell1/VRAC function impairs initial hemodynamics and activates compensatory leukotriene signaling in zebrafish circulation development
These findings link ion-channel function to lipid signalling in vascular development and suggest VRAC/Swell1-5LO cross-talk as a therapeutic target for blood-flow disorders.
Authors
- I.-Hsuan Liu
- Chia-Teng Chang
- Wei‐Chun HuangFu (ORCID: https://orcid.org/0000-0002-6150-9121)
- Yen-Tzu Tseng
Institutions
- National Taiwan University of Science and Technology (TW)
- National Taiwan University (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fcell.2025.1719544
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00