Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung
These data underscore an underappreciated role of eosinophils in homeostatic lung development and suggest that early life modulation of pulmonary eosinophil activity has long-term effects on susceptibility to the development of chronic lung diseases such as asthma.
Authors
- Hitesh S. Deshmukh (ORCID: https://orcid.org/0000-0001-9632-164X)
- Miki Watanabe‐Chailland (ORCID: https://orcid.org/0000-0002-6810-7504)
- David Haslam (ORCID: https://orcid.org/0000-0002-2143-5869)
- William J. Zacharias (ORCID: https://orcid.org/0000-0002-2643-0610)
- Jaclyn W. McAlees (ORCID: https://orcid.org/0000-0002-2589-5010)
- Rabia Ülkü Korkmaz (ORCID: https://orcid.org/0000-0002-2566-5346)
- Ian Lewkowich (ORCID: https://orcid.org/0000-0001-8133-3568)
- Imke Lingel
- James P. Bridges (ORCID: https://orcid.org/0000-0002-4815-117X)
- Yves Laumonnier (ORCID: https://orcid.org/0000-0001-9603-3269)
- Lindsey E. Romick‐Rosendale (ORCID: https://orcid.org/0000-0002-7252-1193)
- Adrienne N. Wilburn (ORCID: https://orcid.org/0000-0003-1035-0955)
- Claire Chougnet
- Julie Hargis
- Inken Schmudde
- Schmaiel Shirdel
- Marc E. Rothenberg (ORCID: https://orcid.org/0000-0001-9790-6332)
- Peter König
- Jörg Köhl
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Helmholtz Zentrum München (DE)
- National Jewish Health (US)
- German Center for Lung Research (DE)
- University of Colorado Anschutz Medical Campus (US)
- University of Cincinnati (US)
- Jewish Hospital (US)
- University of Colorado Denver (US)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1715675
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health