Prolonged impairment of immunological memory after anti-CD20 treatment in pediatric idiopathic nephrotic syndrome: an extended follow-up
Anti-CD20 therapy offers durable disease control and allows immunosuppressant reduction in pediatric INS, but persistent memory B-cell and humoral impairment warrant long-term immunologic monitoring.
Authors
- Giulia Ricci (ORCID: https://orcid.org/0000-0002-2199-170X)
- Antonio Gargiulo (ORCID: https://orcid.org/0000-0002-7139-5412)
- Paolo Palma (ORCID: https://orcid.org/0000-0002-3066-4719)
- Federica Zotta (ORCID: https://orcid.org/0000-0001-9513-9344)
- Barbara Ruggiero (ORCID: https://orcid.org/0000-0003-4442-7201)
- Laura Massella (ORCID: https://orcid.org/0000-0001-5796-3965)
- Francesco Emma (ORCID: https://orcid.org/0000-0002-0383-3468)
- Manuela Colucci (ORCID: https://orcid.org/0000-0003-0969-7521)
- Marina Vivarelli (ORCID: https://orcid.org/0000-0002-2448-1959)
- Nicola Cotugno (ORCID: https://orcid.org/0000-0002-7748-1581)
- Martina Riganati
Institutions
- University of Rome Tor Vergata (IT)
- Bambino Gesù Children's Hospital (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1736921
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero della Salute
- Fondazione Bambino Gesù