Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations
We were able to identify sequence similarities among TBEV responding clones in mice infected with different virus variants. These findings provide valuable insights into the dynamics of T cell responses during acute viral infections and highlight the importance of studying TCR diversity for an in-depth understanding of the immune response.
Authors
- Anastasia A. Minervina (ORCID: https://orcid.org/0000-0001-9884-6351)
- Egor V. Okhezin (ORCID: https://orcid.org/0000-0001-9633-0634)
- Maria A. Salnikova (ORCID: https://orcid.org/0000-0003-4467-5010)
- Yuri B. Lebedev (ORCID: https://orcid.org/0000-0003-4554-4733)
- Ilgar Z. Mamedov (ORCID: https://orcid.org/0000-0002-3992-9285)
- Mikhail V. Pogorelyy (ORCID: https://orcid.org/0000-0003-0773-1204)
- Galina G. Karganova (ORCID: https://orcid.org/0000-0002-8901-6206)
- Ksenia K. Tuchynskaya
Institutions
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Pirogov Russian National Research Medical University (RU)
- Institute of Bioorganic Chemistry (RU)
- Chumakov Institute of Poliomyelitis and Viral Encephalitides (RU)
- Moscow State University (TJ)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1663781
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Higher Education of the Russian Federation