Decoding the exosomal nucleic acid delivery system axis of macrophage autophagy and immune reprogramming via multi-omics analysis
This study provides multi-omics evidence for autophagy modulation mediated by the exosomal nucleic acid delivery system, verifies that this system regulates macrophage autophagy by controlling the TLR4-NF-κB pathway and AMPK/mTOR pathway, and clarifies the application potential of this system in tuberculosis (TB) and other macrophage-associated.
Authors
- Parhat Yasin
- Xinghua Song (ORCID: https://orcid.org/0000-0002-4236-3155)
- Pengchao Zhang (ORCID: https://orcid.org/0000-0002-7851-2976)
- Zhoujun Zhu
- Wei Xiang (ORCID: https://orcid.org/0000-0002-8636-3237)
Institutions
- Xinjiang Medical University (CN)
- Sixth Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fmolb.2025.1711082
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00