Impact of postoperative flurbiprofen axetil on renal function in spontaneously hypertensive rats
Medium-dose FA effectively alleviates postoperative pain and achieves a ceiling effect in SH rats. FA decreases glomerular and tubular function to a certain extent in both normo- and hypertensive rats. Renal impairment is detectable earlier after surgery in hypertensive rats, even at the lowest FA dose applied here.
Authors
- Liang Sun (ORCID: https://orcid.org/0000-0002-4129-3589)
- Xinhua Ma (ORCID: https://orcid.org/0000-0002-6277-0292)
- Weidong Zhang (ORCID: https://orcid.org/0000-0002-4700-1276)
- Yi Feng (ORCID: https://orcid.org/0000-0003-2553-7405)
- Yuhui Jiang
Institutions
- Shijiazhuang University (CN)
- Peking University (CN)
- First Hospital of Shijiazhuang (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fphar.2025.1686334
- Primary Topic
- Veterinary Pharmacology and Anesthesia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China