Histogram analysis of diffusion-weighted imaging with a fractional order calculus model in breast cancer: diagnostic performance and associations with prognostic factors
FROC-based histogram analysis yields diagnostic performance comparable to ADC for benign vs. malignant classification, while providing richer associations with ER/PR status, proliferation, and nodal involvement, reflecting microstructural heterogeneity not captured by mono-exponential diffusion.
Authors
- Caili Tang (ORCID: https://orcid.org/0000-0002-1665-6333)
- Tao Ai (ORCID: https://orcid.org/0000-0002-3735-7500)
- Qilan Hu (ORCID: https://orcid.org/0000-0002-0990-9283)
- Bo Hu (ORCID: https://orcid.org/0000-0002-4234-099X)
- Xu Yan (ORCID: https://orcid.org/0000-0002-9380-2701)
Institutions
- Yichang Central People's Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Siemens (China) (CN)
Publication Details
- Journal
- Frontiers in Radiology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fradi.2025.1664740
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00