MiR-199b-5p inhibition improves inflammation and oxidative stress damage in OA-induced non-alcoholic fatty liver disease through targeting SIRT1
miR-199b-5p is significantly elevated in the serum of NAFLD patients and shows a positive correlation with multiple metabolic indicators. This suggests its potential as a diagnostic biomarker for NAFLD. Additionally, inhibition of miR-199b-5p protects against OA-induced hepatocyte injury, partially through targeting SIRT1, which regulates inflammatory response and oxidative stress.
Authors
- Yaqin Hu (ORCID: https://orcid.org/0000-0003-0637-4209)
- Xuewen Sun
- Lin Tao (ORCID: https://orcid.org/0000-0002-1702-9833)
- Liang Han (ORCID: https://orcid.org/0000-0003-1081-0077)
Institutions
- Guilin Medical University (CN)
- Dalian Medical University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Hanzhong People's Hospital (CN)
- Affiliated Hospital of Guilin Medical College (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s12876-025-04533-3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00