LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity

GHSACA achieves efficient targeted cellular internalization via a macropinocytosis pathway regulated by the LOX1 receptor rather than the CD44 receptor, simultaneously inhibiting the Wnt/β-catenin signaling while activating anti-tumor immune responses. It provides a highly promising translational therapeutic approach for overcoming immune resistance in MSS-CRC.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-12-18
DOI
https://doi.org/10.3389/fimmu.2025.1737031
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
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article

LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity

Xin Wei, Yuyan Guo, Na Chen, Jianyuan Lei
Frontiers in Immunology
Nanoplatforms for cancer theranostics
article

LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity

Xin Wei, Yuyan Guo, Na Chen, Jianyuan Lei
article en

Abstract

GHSACA achieves efficient targeted cellular internalization via a macropinocytosis pathway regulated by the LOX1 receptor rather than the CD44 receptor, simultaneously inhibiting the Wnt/β-catenin signaling while activating anti-tumor immune responses. It provides a highly promising translational therapeutic approach for overcoming immune resistance in MSS-CRC.

Frontiers in ImmunologyVol. 16
Shanxi Medical University (CN), Shaanxi Provincial People's Hospital (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Shanxi Provincial People’s Hospital (CN)
Openalex Percentile: Top 60%
Nanoplatforms for cancer theranostics
DOIOpen Access PDFOpenAlex
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LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity — Xin Wei, Yuyan Guo, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS