Single-cell dissection of PTM-related networks reveals an immunosuppressed osteosarcoma ecosystem
A PTM-anchored transcriptomic signature captures prognostic heterogeneity in osteosarcoma and links adverse outcome to an immunosuppressed microenvironment. GRN emerges as a tumor- and stroma-intrinsic mediator of immune suppression and malignant traits and represents a biologically grounded target for future mechanistic and therapeutic studies.
Authors
- Hanrui Liu (ORCID: https://orcid.org/0000-0003-1854-5693)
- Dongdong Cheng (ORCID: https://orcid.org/0000-0002-4411-9949)
- Jinyu Chen
- Xingyu Zhou (ORCID: https://orcid.org/0009-0001-1832-3348)
- Jingyu Chen (ORCID: https://orcid.org/0000-0002-2127-1788)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-9756-9994)
- Haiping Zhang (ORCID: https://orcid.org/0000-0002-4260-8853)
- Hai Yan (ORCID: https://orcid.org/0000-0001-6380-7096)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second Affiliated Hospital of Nantong University
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fmolb.2025.1718941
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00