High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs
To our knowledge, this study represents the first comprehensive, gene-resolved single-cell analysis to reveal immunoregulatory checkpoint mechanisms underlying immune homeostasis in healthy dogs. Our dataset will serve as a valuable resource for future comparative and translational immunology research in dogs.
Authors
- Chung-Young Lee (ORCID: https://orcid.org/0000-0003-3037-7581)
- Nicholas Borcherding (ORCID: https://orcid.org/0000-0003-1427-6342)
- Woo‐Jin Song (ORCID: https://orcid.org/0000-0002-9195-551X)
- Myung-Chul Kim (ORCID: https://orcid.org/0009-0008-2990-435X)
- Ryan Kolb (ORCID: https://orcid.org/0000-0001-6305-2885)
- Weizhou Zhang (ORCID: https://orcid.org/0000-0002-8236-0346)
- Hyeong-Cheol Seo (ORCID: https://orcid.org/0009-0007-2026-7633)
- Youn Joo Moon
- Taeeun Gu (ORCID: https://orcid.org/0009-0001-8317-9047)
- Young‐Min Yun (ORCID: https://orcid.org/0000-0003-0695-0843)
- Hyun Je Kim (ORCID: https://orcid.org/0000-0003-4467-0949)
- Yubin Kim
Institutions
- Seoul National University (KR)
- Cancer Research Institute (US)
- Washington University in St. Louis (US)
- University of Florida Health (US)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Kyungpook National University (KR)
- University of Florida (US)
- The Schwarzman Animal Medical Center (US)
- Jeju National University (KR)
- Florida College (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1680437
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00