Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome
CLMD exerts its therapeutic effects through multicomponent-multitarget-multipathway synergy that modulates the inflammatory microenvironment, which provides mechanistic insight into relieving the multidimensional symptoms of PMS.
Authors
- Puiian Wong
- Ruoyu Li (ORCID: https://orcid.org/0009-0002-0439-8768)
- Hui Mo
- Yun Qi (ORCID: https://orcid.org/0000-0002-9250-6150)
- Yun Lan
- Bin Fang (ORCID: https://orcid.org/0000-0003-0963-9938)
- Li Ding (ORCID: https://orcid.org/0009-0000-1504-3212)
- Jiaqian Zheng
Institutions
- Macau University of Science and Technology (MO)
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fmolb.2025.1719463
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00