Risk Prediction of Colon Cancer Metastasis and Bioinformatics Analysis of Aspirin Treatment
We developed a validated metastasis gene predictive model. Colon cancer patients with upregulated NOX4, CXCL8, CXCL5, GDF15, or MMP13 may not benefit from aspirin chemoprophylaxis. Conversely, patients showing aspirin-induced downregulation of E2F1, CCNE1, VEGFA, and MMP3 may derive chemoprophylactic benefit.
Authors
- Xiaolin Yu (ORCID: https://orcid.org/0000-0003-0379-5622)
- Jiawei Yu (ORCID: https://orcid.org/0009-0005-9793-1067)
- Jing Li (ORCID: https://orcid.org/0000-0002-9032-3772)
- Jingjing Shao (ORCID: https://orcid.org/0000-0003-4656-1500)
- Hui Zhang (ORCID: https://orcid.org/0009-0005-3796-0384)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Nantong Tumor Hospital (CN)
Publication Details
- Journal
- International Journal of Genomics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/ijog/8412254
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00