Whole genome sequencing confirms reactivation of tuberculosis five years after initial infection despite adequate preventative therapy in a patient with profound immunosuppression
TBI can reactivate under profound immunosuppression even after prior prophylaxis. Clinicians should maintain vigilance for reactivation in high-risk patients, and WGS should be performed to guide diagnosis, treatment, and epidemiological understanding.
Authors
- E McNally (ORCID: https://orcid.org/0000-0003-0469-7135)
- Emma Roycroft (ORCID: https://orcid.org/0009-0003-2969-8668)
- Shelagh O’Riordan
- Margaret Fitzgibbon (ORCID: https://orcid.org/0000-0001-8822-214X)
- Catherine Flynn (ORCID: https://orcid.org/0000-0001-7645-3469)
- Lorraine Dolan
- Anne-Marie McLaughlin (ORCID: https://orcid.org/0000-0001-9861-9714)
- Joseph Keane (ORCID: https://orcid.org/0000-0001-5313-385X)
Institutions
- Trinity College (CA)
- Trinity College Dublin (IE)
- Laboratoire National de Référence (MA)
- St. James's Hospital (IE)
Publication Details
- Journal
- QJM
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1093/qjmed/hcaf326
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00