Age-related differences in choroid plexus structural integrity are associated with changes in cognition
These findings highlight the importance of CP integrity in maintaining cognitive health and suggest that a holistic approach to assessing CP integrity could serve as a sensitive biomarker for early detection of cognitive decline. Further research is needed to elucidate the mechanisms underlying the relationship between CP structural integrity and clinical decline and to explore the potential therapeutic implications of targeting CP function to prevent or treat age-related cognitive deficits.
Authors
- Josephine Mary Egan (ORCID: https://orcid.org/0000-0002-8945-0053)
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Mustapha Bouhrara (ORCID: https://orcid.org/0000-0001-6184-669X)
- Alexandre Rouen (ORCID: https://orcid.org/0000-0003-1098-6611)
- Samuel Klistorner (ORCID: https://orcid.org/0000-0001-5761-5178)
- Nathan Zhang (ORCID: https://orcid.org/0000-0003-3111-5794)
- Joseph S. R. Alisch (ORCID: https://orcid.org/0000-0002-8500-6262)
- Zhaoyuan Gong (ORCID: https://orcid.org/0000-0001-6488-5424)
- Caio Henrique Mazucanti (ORCID: https://orcid.org/0000-0001-9144-4886)
- Jonghyun Bae (ORCID: https://orcid.org/0000-0002-3987-6603)
- Alexander Y. Guo (ORCID: https://orcid.org/0000-0002-1284-8768)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Alexander Klistorner (ORCID: https://orcid.org/0000-0003-0361-6399)
- Yang An (ORCID: https://orcid.org/0000-0002-6529-1609)
- Noam Y. Fox
Institutions
- The University of Sydney (AU)
- National Institutes of Health (US)
- Institute on Aging (US)
- National Institute on Aging (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s12987-025-00749-3
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00