Dosing and safety of amphotericin B deoxycholate in paediatric American cutaneous leishmaniasis in Peru: a case series
Intravenous amphotericin B deoxycholate (AmB-d) is an effective and well-tolerated second-line treatment for paediatric American CL unresponsive to Sb<sup>5+</sup> treatment. Despite the need for high cumulative doses, prolonged treatment durations, and frequent AEs, side effects were mild to moderate, transient, and did not lead to treatment discontinuation.
Authors
- Roger Hernández (ORCID: https://orcid.org/0000-0002-1906-9599)
- Bryan S. Jordan (ORCID: https://orcid.org/0000-0003-1928-4632)
- John C. Gallegos
- Alejandro Llanos‐Cuentas (ORCID: https://orcid.org/0000-0002-7567-5534)
- Fiorela Alvarez (ORCID: https://orcid.org/0000-0002-3577-6613)
- Joel Lopez
- Eduardo Verne
- Mercedes Sanchez‐Diaz (ORCID: https://orcid.org/0009-0004-9914-5441)
- Elsa Gonzales Lagos
Institutions
- Universidad Peruana Cayetano Heredia (PE)
- Universidad de San Martín de Porres (PE)
- Hospital Nacional Cayetano Heredia (PE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s12879-025-12344-w
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00