Nanozyme-armored natural enzymes for acute kidney injury management via inflammation regulation and oxidative damage mitigation
This study successfully developed a CAT@MnS nanozyme that integrates ROS scavenging with inflammation regulation. The biomimetic mineralization strategy enhanced the stability and therapeutic synergy of the system. The nanozyme offers a new approach for the synergistic treatment of AKI and shows promising potential for translational application.
Authors
- Shuai Huo
- Xiaofei Fu
- Fengmin Shao (ORCID: https://orcid.org/0000-0003-2905-4312)
- Yue Gu
- Juntao Wang (ORCID: https://orcid.org/0000-0002-4072-9870)
- Ruifeng Li (ORCID: https://orcid.org/0000-0002-3158-6337)
- Lijiao Wang (ORCID: https://orcid.org/0000-0002-7708-2062)
Institutions
- Zhengzhou University (CN)
- Shangqiu First People's Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fphar.2025.1686323
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00