Notoginsenoside R1 mitigates UVB-induced skin sunburn injury through modulation of N4-acetylcytidine and autophagy
PNS and NGR1 demonstrate promising therapeutic potential for the treatment of UVB-induced skin sunburn injury. Their capacity to mitigate photodamage via multiple mechanisms, such as inhibition of key signaling pathways, regulation of apoptosis and autophagy, and modulation of NAT10 expression, lays a strong foundation for future clinical studies on topical applications of PNS and NGR1, while also providing valuable insights into their preventive and curative effects.
Authors
- Jiyu Gong (ORCID: https://orcid.org/0000-0001-8573-1870)
- Yuting Yang (ORCID: https://orcid.org/0000-0003-3808-3940)
- Xiaobo Sun (ORCID: https://orcid.org/0000-0001-9876-5666)
- Tong Zhang (ORCID: https://orcid.org/0000-0003-1036-7060)
- De‐an Guo
- Xiaokang Liu (ORCID: https://orcid.org/0000-0001-5614-1601)
- Fangyuan Zhang (ORCID: https://orcid.org/0009-0004-3253-4661)
- Zizhao Yang
- Shuyun Liang
Institutions
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Institute of Materia Medica (CN)
- Changchun University of Chinese Medicine (CN)
- Seventh People's Hospital of Shanghai (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s13020-025-01270-3
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00