Selectivity and stability reshaping high-sensitivity detection boundaries: A technical leap and paradigm shift in semiconductor surface-enhanced Raman scattering
This Perspective commemorates 50 years of surface-enhanced Raman scattering (SERS) by highlighting the paradigm shift toward rationally designed semiconductor substrates, enabling ultrasensitive and molecule-selective detection. Several enhancement strategies have been developed to effectively modulate the electronic band structure and charge transfer (CT) processes, such as energy level customization, amorphization, quasi-metallization, and morphology control, achieving high enhancement factors with good selectivity and stability. Moreover, semiconductor SERS substrates show broad prospects in the fields of bio-sensing and cancer diagnosis. Nevertheless, standardization gaps in substrate reproducibility and data comparability hinder its widespread adoption. Resolving these challenges through multi-stakeholder collaboration is essential to bridge the technology transfer gap and establish SERS as a core platform for next-generation inspection.
Authors
- J.-C. Lin (ORCID: https://orcid.org/0000-0003-4211-2302)
- Fugang Xu (ORCID: https://orcid.org/0000-0002-4165-8437)
- Xiangyu Meng (ORCID: https://orcid.org/0000-0001-6740-5975)
- Tingting Zheng
- Lei Chen (ORCID: https://orcid.org/0000-0003-2616-2190)
- Aiguo Wu (ORCID: https://orcid.org/0000-0001-7200-8923)
- Wei Ji
- Teng Qiu (ORCID: https://orcid.org/0000-0002-1160-2619)
- Xingce Fan (ORCID: https://orcid.org/0000-0002-2508-3063)
- Guangcheng Xi (ORCID: https://orcid.org/0000-0002-8486-9613)
- Zhigang Zhao (ORCID: https://orcid.org/0000-0002-6707-0914)
- Shan Cong (ORCID: https://orcid.org/0009-0006-0750-6890)
- Aiguo Shen (ORCID: https://orcid.org/0000-0002-2512-3221)
- Yusi Peng (ORCID: https://orcid.org/0000-0003-1711-9473)
- Libin Yang (ORCID: https://orcid.org/0000-0002-9658-8640)
- Yong Yang
- Y. G. Xie (ORCID: https://orcid.org/0000-0002-0170-2798)
- Kun Liang (ORCID: https://orcid.org/0000-0003-2494-4025)
- Xiaotian Wang (ORCID: https://orcid.org/0009-0001-4872-6754)
Publication Details
- Journal
- Nano Research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.26599/nr.2026.94908347
- Citations
- 3
- Primary Topic
- Gold and Silver Nanoparticles Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.28
Funders
- National Natural Science Foundation of China