Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009–2018
Basic sepsis care implementation remains challenging even in high-income settings. Empirical broad-spectrum antibiotic usage has outpaced AMR risk. Full sepsis bundle adherence was associated with improved survival, but empirical broad-spectrum antibiotics was associated with better survival only if used appropriately. Efforts should focus not only on ensuring bundle adherence but also on prioritizing the right treatments for the right patients.
Authors
- Peng Wu (ORCID: https://orcid.org/0000-0003-1157-9401)
- Ting Liong
- Alwin Wai Tak Yeung
- Ka Man Fong (ORCID: https://orcid.org/0000-0003-1491-5335)
- Lowell Ling (ORCID: https://orcid.org/0000-0001-6639-7344)
- Jack Zhenhe Zhang (ORCID: https://orcid.org/0000-0001-7114-7761)
- Pauline Yeung Ng (ORCID: https://orcid.org/0000-0001-6671-5963)
- Kwok Ming Ho (ORCID: https://orcid.org/0000-0002-6705-6004)
- Manimala Dharmangadan
- Ka Fai Au
- Man Yee Man
- Chanu Rhee (ORCID: https://orcid.org/0000-0002-9537-4245)
- Eunise Ho
- Michele W. Tang
- William Ka Kei Wu (ORCID: https://orcid.org/0000-0002-5662-5240)
- Steven Ling (ORCID: https://orcid.org/0000-0001-6395-3624)
- Lok Ching Sandra Chiu (ORCID: https://orcid.org/0000-0002-8218-2359)
- Benjamin J. Cowling (ORCID: https://orcid.org/0000-0002-6297-7154)
- Jacky Ka Hing Chan
- Katy Hoi Ki Li
- Anna Lee (ORCID: https://orcid.org/0000-0003-2864-0045)
- Lok Ching Chang
- Chun Hei Chan
- Wai Tat Wong
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Chinese University of Hong Kong (HK)
- Kwong Wah Hospital (CN)
- Tuen Mun Hospital (CN)
- Queen Mary Hospital (CN)
- Hong Kong Science and Technology Parks Corporation (HK)
- United Christian Hospital (CN)
- North District Hospital (HK)
- Tseung Kwan O Hospital (CN)
- Pamela Youde Nethersole Eastern Hospital (CN)
- Alice Ho Miu Ling Nethersole Hospital (CN)
- Caritas Medical Centre (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Queen Elizabeth Hospital (GB)
- Tang Shiu Kin Hospital (CN)
- Harvard Pilgrim Health Care (US)
- Prince of Wales Hospital (CN)
- Princess Margaret Hospital (HK)
- Queen Elizabeth Hospital (CN)
- Laboratory of Data Discovery for Health (HK)
- University of Hong Kong (HK)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1093/ofid/ofaf752
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health and Medical Research Fund