CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming
Our findings identify CD300e as a critical regulator of macrophage-mediated immune suppression in CRC and a potential target for reprogramming TAMs to enhance immunotherapy.
Authors
- Stefania Vassallo (ORCID: https://orcid.org/0009-0003-6954-9675)
- Gaia Codolo (ORCID: https://orcid.org/0000-0002-7793-2549)
- Annica Barizza (ORCID: https://orcid.org/0000-0003-1791-6333)
- Silvia Lonardi (ORCID: https://orcid.org/0000-0003-0307-4163)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Sara Coletta (ORCID: https://orcid.org/0000-0001-5465-127X)
- Silvano Sozzani (ORCID: https://orcid.org/0000-0002-3144-8743)
- William Vermi (ORCID: https://orcid.org/0000-0002-2291-2997)
- Chiara Della Bella (ORCID: https://orcid.org/0000-0002-2565-6220)
- Antonio Rosato (ORCID: https://orcid.org/0000-0002-5263-8386)
- Roberta Sommaggio (ORCID: https://orcid.org/0000-0002-5682-5867)
- Laura Masatti (ORCID: https://orcid.org/0009-0002-2610-4265)
- Gaya Spolverato (ORCID: https://orcid.org/0000-0002-7275-2573)
- Mario Milco D’Elios (ORCID: https://orcid.org/0000-0001-9160-0930)
- Mattia Laffranchi (ORCID: https://orcid.org/0000-0002-0556-6068)
- Enrica Calura (ORCID: https://orcid.org/0000-0001-8463-2432)
- Mattia Bugatti (ORCID: https://orcid.org/0000-0003-3776-8497)
- Simone Pizzini (ORCID: https://orcid.org/0009-0006-0584-7982)
- S. Giacometti (ORCID: https://orcid.org/0009-0004-7977-5411)
Institutions
- University of Siena (IT)
- University of Padua (IT)
- Istituto Oncologico Veneto (IT)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-013249
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80