Preclinical safety assessment of holmium-based microspheres for micro-brachytherapy in mice
These findings indicate that the injection fluid (MCC in phosphate buffer) in combination with Ho-(OH)<sub>3</sub>-MS or Ho-PLLA-MS can potentially be used as administration fluid for controlled localized microsphere delivery. However, prior to clinical application, clinically relevant doses have to be tested in sensitive anatomical regions.
Authors
- Sebastiaan A. van Nimwegen (ORCID: https://orcid.org/0000-0002-5366-0120)
- Nienke Johanna Maria Klaassen (ORCID: https://orcid.org/0000-0001-8898-4005)
- Janneke D.M. Molkenboer‐Kuenen (ORCID: https://orcid.org/0009-0007-0879-5660)
- Alexandra Arranja
- Nino Chiron Morsink
- J. Frank W. Nijsen (ORCID: https://orcid.org/0000-0001-7625-2253)
- Milou Boswinkel
- Guy C. M. Grinwis (ORCID: https://orcid.org/0000-0002-1583-9648)
- Jan Willem Hesselink (ORCID: https://orcid.org/0000-0001-6378-9721)
Institutions
- Radboud University Nijmegen (NL)
- University of Applied Sciences Utrecht (NL)
- Utrecht University (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Deventer Ziekenhuis (NL)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1016/j.ejps.2025.107419
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00