Sirolimus for Recurrent Chylothorax and Edema in an Infant with Noonan Syndrome after Resolved Hydrops Fetalis: A Case Report
Although sirolimus was ineffective in this case, initiation of treatment at a lower dose may be advisable for patients with compromised hepatic function or concurrent infections. Further studies are warranted to clarify the appropriate indications, dosage, and timing of sirolimus therapy for Noonan syndrome.
Authors
- Michio Ozeki (ORCID: https://orcid.org/0009-0003-0224-4201)
- Kei Tamai (ORCID: https://orcid.org/0000-0002-3343-1590)
- Mariko Hattori (ORCID: https://orcid.org/0000-0003-2802-8016)
- Misao Kageyama (ORCID: https://orcid.org/0000-0003-3815-9546)
- Akihito Takeuchi (ORCID: https://orcid.org/0000-0003-4332-4075)
- Makoto Nakamura (ORCID: https://orcid.org/0000-0001-5234-4487)
- Hirokazu Watanabe
Institutions
- Okayama Medical Center (JP)
- Gifu University (JP)
Publication Details
- Journal
- American Journal of Perinatology Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1055/a-2770-4952
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00