Real-world data of verteporfin-related ocular adverse events: A disproportionality analysis

The most common verteporfin-related ocular AEs (reduced visual acuity, retinal haemorrhage and choroidal neovascularization) were consistent with the drug label. However dozens of new potential ocular AEs with strong signal strengths that were not listed in the drug label, were identified. It should be noted that the proportional data in the study cannot provide information about other drugs used for the same indications as verteporfin. A fully-comprehension of these AEs will be highly beneficial in deciding which patients should be closely monitored for verteporfin-related ocular AEs. However, we emphasis our view that this study should be supported by prospective, clinically conducted research, as data on verteporfin's therapeutic indications and dosage are unavailable in this study.