Peptidoglycan from <i>Bifidobacterium bifidum</i> G9-1 induces IgA secretion in Peyer’s patch-derived cells
Immunoglobulin A (IgA) plays a key role in mucosal immunity. We investigated the IgA-inducing capacity of heat-killed <i>Bifidobacterium bifidum</i> G9-1 (BBG9-1) using Peyer's patch (PP)-derived cells. Heat-killed BBG9-1, but not its culture supernatant, significantly enhanced IgA secretion and cell aggregation. Compared with other Gram-positive bacteria, BBG9-1 showed a stronger IgA-inducing effect. Component analysis revealed that peptidoglycan (PG), but not lipoteichoic acid (LTA), isolated from BBG9-1 significantly stimulated IgA secretion. These findings suggest that PG from BBG9-1 is a key factor in IgA induction, supporting its potential application in modulating mucosal immune responses.
Authors
- T. Dokoshi
- Aki Sakatani (ORCID: https://orcid.org/0000-0001-7975-2413)
- Yutaka Makizaki (ORCID: https://orcid.org/0000-0001-7971-7503)
- Hiroshi Ohno (ORCID: https://orcid.org/0000-0001-8776-9661)
- Yoshiki Tanaka (ORCID: https://orcid.org/0000-0003-0050-587X)
- Kentaro Moriichi (ORCID: https://orcid.org/0000-0002-1298-3265)
- Hiroaki Konishi (ORCID: https://orcid.org/0000-0002-6477-721X)
- Koji Yamamoto (ORCID: https://orcid.org/0000-0002-7345-6100)
- Mikihiro Fujiya
Institutions
- Asahikawa Medical College Hospital (JP)
- Asahikawa Medical University (JP)
- Kobe Pharmaceutical University (JP)
- LTT Bio-Pharma (Japan) (JP)
Publication Details
- Journal
- Bioscience of Microbiota Food and Health
- Published
- 2025-12-17
- DOI
- https://doi.org/10.12938/bmfh.2025-040
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00