Exploring the Role of the Extracellular Matrix in Disease and Aging

Throughout my research career, I have focused on understanding the extracellular matrix (ECM) and its roles in disease pathogenesis and the aging process. My initial interest in muscular dystrophies gradually expanded to include various organs and systems, including the kidneys, brain, cartilage, skin, and eyes. During my tenure at the National Institutes of Health (NIH), I made substantial contributions to generating and analyzing conditional knockout mouse models for key ECM molecules, including laminin α1 and perlecan. These studies elucidated the roles of ECM components in hereditary diseases, embryonic development, and the functionality of the neuromuscular junction. Upon returning to Japan, I transitioned this foundational expertise into translational research across multiple fields, benefiting from a collaborative environment that bridges basic and clinical sciences. My recent work examines the impact of glycosylation on ECM remodeling. Reflecting on this scientific journey, I emphasize the importance of ECM as a structural component and as a dynamic regulator of cellular behavior. As I retire from active academic life, I aspire to support the next generation of scientists in exploring the extracellular space, an area rich with potential therapeutic opportunities.