PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8 <sup>+</sup> T cell dysfunction
This study reveals the pivotal role of the hepatic cell-intrinsic enzyme PCK1 in mediating CD8<sup>+</sup> T cell dysfunction via 12-HETE-p38 signalling in MASH-HCC. PCK1 could be a metabolic checkpoint to enhance the efficacy of anti-PD-1 immunotherapy in MASH-HCC.
Authors
- Renming Liu (ORCID: https://orcid.org/0000-0002-0088-7583)
- Aishun Jin
- Haijun Deng (ORCID: https://orcid.org/0000-0002-4890-192X)
- Ailong Huang (ORCID: https://orcid.org/0000-0003-0148-7423)
- Luyi Huang (ORCID: https://orcid.org/0000-0002-0377-877X)
- Kai Wang (ORCID: https://orcid.org/0000-0002-0137-1247)
- Xiaojian Han (ORCID: https://orcid.org/0000-0003-0477-7522)
- Ni Tang (ORCID: https://orcid.org/0000-0001-5830-8786)
- Chen Shi (ORCID: https://orcid.org/0000-0001-8728-463X)
- Xinyu Liu (ORCID: https://orcid.org/0000-0002-5180-6958)
- Zhirong Zhang (ORCID: https://orcid.org/0000-0001-9118-5394)
- Qiang He (ORCID: https://orcid.org/0000-0003-2434-1275)
- Xiaosong Li (ORCID: https://orcid.org/0000-0001-5533-7995)
- Jianghong Zheng
- Chen Chang (ORCID: https://orcid.org/0000-0001-8408-0906)
- Li Luo (ORCID: https://orcid.org/0000-0002-3503-9998)
- Fengli Xu (ORCID: https://orcid.org/0000-0002-9882-8900)
- Yi Liu (ORCID: https://orcid.org/0000-0001-6180-8175)
- Kang Wu (ORCID: https://orcid.org/0009-0000-3249-842X)
- Huijun Liang (ORCID: https://orcid.org/0000-0001-7344-1489)
Institutions
- Sun Yat-sen University (CN)
- Chongqing University (CN)
- Runze (China) (CN)
- People's Hospital of Bishan District (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Emergency Medical Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Chongqing Cancer Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1136/gutjnl-2024-334562
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00