Use of Ascorbic Acid in Postreperfusion Syndrome During Orthotopic Liver Transplantation: A Case Report

Postreperfusion syndrome is a complication seen after graft reperfusion in liver transplantation. Anesthesiologists counter this physiological response with a variety of medications including high-dose vasopressors, hydrocortisone, methylene blue, and hydroxocobalamin. These treatment modalities are contingent on availability, a fact brought to light by a national shortage of hydroxocobalamin in 2025. Subsequently, hospitals earmarked its use specifically for patients with cyanide poisoning. In this case report, we describe the use of ascorbic acid as a potential adjunct for the treatment of postreperfusion syndrome during liver transplantation.